Anti wrinkles with BOTOX
Botulinum toxin is a naturally occurring protein produced by the bacterium Clostridium botulinum
Botulinum toxin can be used to treat all wrinkles, which are the result of normal facial movement. When it is injected into a specific muscle in the face it blocks the signal from the nerve to the muscle. This means that the nerve ending cannot tell the muscle to move, hence there will be less wrinkling of the skin in the areas treated. The upper third of the face is where the best treatment results are obtained, commonly for the reduction in crow's feet around the eyes and wrinkles on the forehead and between the eyebrows. Depending on the area treated, dose used, and how you respond, repeat treatments will be required around every 3 - 6 months.
Currently the number one non-surgical aesthetic treatment in the World, Botox® is the leading brand of botulinum toxin type - A in terms of documented clinical trials and practical use around the globe.
Botox® was the first botulinum toxin to gain a cosmetic licence endorsing its use for glabellar lines and wrinkles. It is approved for this indication in the U.S. and around the world.
Generic name of Botox®
Clostridium botulinum type - A neurotoxin complex.
How is it manufactured?
Botox® is made from purified type - A neurotoxin produced by the bacteria Clostridium botulinum.
How does Botox® work?
It temporarily prevents the release of acetycholine from sympathetic nerve terminals.
Botox® is licenced for blepharospasm, hemifacial spasm, cervical dystonia, severe hyperhidrosis of the axillae, dynamic equinus foot deformity due to spasticity in ambulant paediatric cerebral palsy patients, two years of age or older, and for wrist and hand disability due to upper limb spasticity associated with stroke in adults.
Who should not have Botox® treatment?
Individuals with a known hypersensitivity to any component of the formulation.
Patients who have generalised disorders of muscle activity (e.g. myasthenia gravis).
Patients where aminoglycoside antibiotics or spectinomycin are already being used or are likely to be used.
Patients who have bleeding disorders of any type.
Pregnant or lactating women.
Reported side effects associated with the cosmetic use of Botox® include
Bruising or bleeding at the site of injection, headache, and rarely eyelid ptosis or diplopia, and brow droop.
Botox® clinical results
Most of the literature on Botulinum Toxin, and hence the clinical evidence and statistics, are based on Botox® as this brand represents around 80% of the world’s use of Botulinum Toxin.
Because it is a prescription only medicine; it had to undergo strict clinical trials in the U.S., where it is approved for cosmetic use, in order to gain a license. Remember, the drug has been licensed in the U.S. since the late 1980s.
The graph below shows the results of a study published in 2001.
• 500 patients were injected three times in a year with Botox®.
• They were injected on days 0, 120 and 240.
• The graph shows that over 70% of the patients showed significant improvement in their glabellar frown lines (i.e. the appearance of their wrinkles when trying not to frown) 30 days after their first injections.
• This improvement continued after repeat Botox® injections at days 120 and 240.
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